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QD community oral or SC MOTS-c Daily SC, often 5 days on / 2 off AOD-9604 Daily SC Attribute Max studied dose SLU-PP-332 50 mg/kg BID (mouse, 28 days) MOTS-c 5-15 mg/kg (mouse) AOD-9604 1-5 mg/day in human Phase 2 Attribute Peak efficacy signal SLU-PP-332 ~25-30% fat-mass reduction in DIO mice over 28 days MOTS-c Improved insulin sensitivity in aged mice AOD-9604 Modest fat-loss signal in human Phase 2

While these medications are generally safe and may even benefit liver health, individualized assessment ensures appropriate patient selection and monitoring strategies

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However, a recent study suggested that the introduction of CRISPRCas9 induced the emergence and amplification of TP53 inactivation mutations