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[250] [251] The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N -oxidation, N -dealkylation, and deamination

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Several authorities, including the World Health Organization, feel there is not enough evidence to recommend e-cigarettes for quitting smoking, and there are studies showing a decline in smoking cessation among dual users [22, 23]

Online advertising This was a categorial variable with a dichotomous response (yes/no) that was constructed from an affirmative response to at least one of the following questions: During the past 30 days, did you see any advertisements for tobacco products on the Internet or social network (Facebook, YouTube, Snapchat)?