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The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

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This decoupling a short-lived peptide carrying a persistent metal is the key pharmacological feature of systemic GHK-Cu and the reason copper balance, not peptide half-life, is the dominant safety consideration

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[DOI] [PMC free article] [PubMed] [Google Scholar] 229.Ye LF, Chaudhary KR, Zandkarimi F, Harken AD, Kinslow CJ, Upadhyayula PS, et al

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