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With the highest 12 mg dose of retatrutide (Eli Lilly) an investigational #GLP1, glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptor agonist nearly two-thirds of participants lost 20% or more of their body weight, half of participants lost 25% of their body weight and one-quarter of participants lost more than 30% of their body weight

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J Exp Biol 205(Pt 3):297306 Zeisel SH, Warrier M (2017) Trimethylamine N-Oxide, the microbiome, and heart and kidney disease

Such evidence, however, is supported by many relevant pre-clinical or mechanistic studies highlighting the neuroprotective and anti-inflammatory activity of these medications