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People with G6PD deficiency should avoid high doses or combinations with vitamin C, as this may cause harmful side effects like red blood cell breakdown

One trial had 71 women with mild to advanced signs of photoaging apply a facial cream containing GHK-Cu daily for three months

In laboratory research, GHK-Cu is utilized in gene expression profiling experiments (documented effects on 4,000+ human genes), extracellular matrix research gene expression studies (collagen I, III, IV), matrix metalloproteinase (MMP-1, MMP-2, MMP-9) and TIMP regulation assays, glycosaminoglycan deposition measurements, decorin and integrin expression studies, superoxide dismutase (SOD) activity assays, and investigations of VEGF, FGF-2 expression modulation