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"Tobacco Fact Sheet"

Active smokers had significantly lower odds of having ANA than nonsmokers in Period 2, as would be expected if CO is protective, but this evident reduction was weaker (and not significant) in Periods 1 and 3

This chemical reaction not only creates a sense of enjoyment and relaxation shortly after using tobacco but also leads to withdrawal symptoms when the nicotine levels in the bloodstream drop, compelling the user to seek out more tobacco to alleviate these uncomfortable effects