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The rationale, from a pharmacological standpoint, is that retatrutide's action on GLP-1, GIP, and glucagon receptors drives significant caloric deficit and improved insulin sensitivity, whilst sermorelin's stimulation of endogenous growth hormone release may support lipolysis and muscle protein synthesis

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Clinical Considerations for Managing Patients at Risk When prescribing GLP-1 receptor agonists, clinicians should consider individual patient risk factors for atrial fibrillation

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