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Laboratory studies have demonstrated potential neuroprotective effects, including reducing oxidative stress, decreasing inflammation, promoting neuronal survival, and enhancing mitochondrial functionall processes that are impaired in Parkinson's disease

Although GLP-1 RAs tend to be priced higher than other anti-diabetic drugs, cost-utility reviews point to the overall cost-effectiveness of semaglutide due to its proven long-term benefits

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123 Following promising preclinical findings, several clinical trials have been initiated to evaluate the neuroprotective efficacy of GLP-1RAs in diverse populations, including individuals with diabetes, those at risk of cognitive decline, and patients diagnosed with AD or PD