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1 Introduction At present, depression has become a major mental illness worldwide ( Bifidobacterium ), and depressive symptoms is more directly measurable (e.g., via SCFA levels, neurotransmitter concentrations) than the vague association between overall diet and mood ( The gut-brain axisa bidirectional communication network involving the central nervous system (CNS), enteric nervous system (ENS), and gut microbiotaprovides a key framework for understanding nutrition-microbiota-depression interactions ( Bifidobacterium ) in depressed patients ( 2 Methods 2.1 Literature search strategy This review followed a systematic approach aligned with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines ( Search databases: a systematic search will be conducted across four major databases: PubMed, Web of Science Core Collection, Embase, and Cochrane Library