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Although there is no data in humans, GLP-1RAs should not be used in patients with a past or family history of medullary thyroid cancer or in patients with multiple endocrine neoplasia type 2

Heart disease, liver disease or kidney disease patients require medical supervision [47]

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After 20 min at room temperature, chromatin configurations were analyzed using fluorescence microscopy (Eclipse 80i, Nikon Instruments Europe, Amsterdam, The Netherlands) at 40 magnification with an excitation (Ex) filter of 365/28 nm, a dichroic mirror (DM) of 405 nm and an emission (Em) filter of 445/50 nm