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As a fatty acid amide, PEA interacts with the peroxisome proliferator-activated receptor alpha (PPAR-$\alpha$) and G-protein coupled receptors to down-regulate mast cell activation, offering an advanced model for studying the mitigation of visceral pain and chronic neuro-inflammatory signaling along the enteric nervous system

For most patients, a weekly B12 shot for the first four weeks rebuilds depleted B12 levels, followed by maintenance shots every two to four weeks

Clinically supervised topical use, with pharmaceutical-grade formulations, is the safest approach