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Notably, large outcome trials have documented cardiovascular benefits

has synthesized carboxy-benzimidazoles acting as glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of arthritis, diabetes, eating disorders, macular degeneration, myocardial infarction, nonalcoholic steatohepatitis, sleep apnea and Parkinson's disease, among others

Chronic disruption and uncoupling of these interfaces are increasingly recognized as a hallmark of metabolic disorders, including obesity, type 2 diabetes (T2DM), and metabolic dysfunction-associated steatohepatitis (MASH) (Rieusset, 2018)

Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut