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As of mid-2025, the FDA documented 605 adverse event reports specifically related to compounded semaglutide

In clinical trials, severe gastrointestinal adverse reactions were reported more frequently among patients who received semaglutide tablets (7 mg 0.6%, 14 mg 2%) than placebo (0.3%)

The FDA safety-risk summary notes that compounded drugs containing MOTS-C may pose risks related to immunogenicity, peptide-related impurities, and active pharmaceutical ingredient characterization

While GLP-1 drugs alone deliver powerful effects on blood sugar, appetite, and weight loss, the bodys energy balance and metabolism are controlled by multiple hormonal pathways