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The metabolic pathways of new drugs should be determined to predict the possibility of adverse drug reactions and drug-drug interactions

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Other isothiocyanates have been shown to prevent the degradation of the NF-B inhibitor, IB, the nuclear translocation of NF-B, and/or the transcriptional activity of NF-B in vitro or in cultured cells ( Figure 3 ) (20), which all can lead to a decrease in inflammatory responses