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Cross-trial comparisons with dual-agonist agents such as tirzepatide are exploratory only no head-to-head trials have been conducted and should be interpreted with caution

It is particularly relevant for patients with widespread plaques or psoriatic arthritis where systemic immune modulation is desirable

in many regions it is prescription-only and should be used under medical supervision to avoid masking other causes of neuropathy

Clinical trials demonstrate safety and efficacy with EPA (1.6 g) + DHA (0.8 g) daily for 12 weeks in lung cancer patients, showing improved nutritional status and suppressed inflammatory markers (CRP, TNF-, IL-6) (63)