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Avoid greasy, spicy, and overly sweet foods during the first 4 weeks

End-of-week appetite return during the first four to eight weeks is a normal pharmacokinetic phenomenon, not a sign of treatment failure

The availability of semaglutide has coincided with a broader shift in CKD care, driven by an expanding number of therapies capable of delaying disease progression and reducing the likelihood of dialysis or kidney transplantation

Hepatocyte models have been used to investigate effects on glucose output and lipogenic gene expression, while 3T3-L1 and primary adipocyte cultures have characterised effects on lipolysis, GLUT4 translocation, and adipokine secretion