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It is suggested that individuals with low GPx activity are prone to intact antioxidant protection leading to oxidative damage to membrane fatty acid and functional proteins and consequently to neurotoxic damage [56]

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Moreover, the availability of multiple effective obesity pharmacotherapies with different mechanisms of action will provide clinicians the opportunity to select treatments based on patient preference, underlying comorbidities, medication safety profile and treatment response, with an aim to achieve the individualised WL targets, improve the overall health and/or the quality of life [7]

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