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Three randomly selected mice from each group were euthanized before intervention at 8 weeks

This study confirmed the findings of an earlier pooled analysis of 25 randomised clinical trials totalizingsimilarly to the TECOS trialalmost 15,000 patients, which did not indicate that treatment with sitagliptin increases cardiovascular risk in patients with T2DM [76]

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J Clin Endocrinol Metab 94:846852 Nogueiras R, Perez-Tilve D, Veyrat-Durebex C et al (2009) Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity